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[Timotheus Pokorra]

> Oct 24 16:58:55 mail clamd[22221]: /usr/sbin/clamd: unrecognized option `--nofork=yes'
> Oct 24 16:58:55 mail clamd[22221]: ERROR: Unknown option passed
> Oct 24 16:58:55 mail clamd[22221]: ERROR: Can't parse command line options

This error message leads me to this answer:
https://www.centos.org/forums/viewtopic.php?t=58763#p248129

Try to edit /usr/lib/systemd/system/clamd at .service and change the
ExecStart line to:
ExecStart = /usr/sbin/clamd -c /etc/clamd.d/%i.conf --foreground=yes

Timotheus